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Writer's pictureMark Ayzenberg

PRP: The Cutting Edge of Knee Osteoarthritis Treatment: A Comprehensive Review of Research Studies

Knee osteoarthritis (OA) is a common degenerative joint condition characterized by cartilage deterioration, pain, and functional impairment. In recent years, Platelet-Rich Plasma (PRP) therapy has emerged as a potential treatment modality for knee OA, offering a promising alternative to traditional interventions such as medication, cortisone or surgery. In this blog post, we delve into the body of research examining the efficacy of PRP therapy for knee OA, providing insights into its potential benefits and clinical outcomes.

Research Studies on the efficacy of PRP as well as multiple comparing PRP to compared to Steroid (Cortisone) and  Hyaluronic acid ("gel"/"lubricant") Injections for Knee Osteoarthritis:


  1. Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee Osteoarthritis Click here for link to study.

  2. Clinical and Biochemical Correlation of Intra-articular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee Click here for link to study.

  3. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial) Click here for link to study.

  4. Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial Click here for link to study.

  5. Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis Click here for link to study.

  6. Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial Click here for link to study.

  7. Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial Click here for link to study.

  8. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study Click here for link to study.

  9. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial Click here for link to study.

  10. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial) Click here for link to study.


The body of research on Platelet-Rich Plasma (PRP) therapy for knee osteoarthritis (OA) suggests promising outcomes in terms of pain relief, functional improvement, and patient satisfaction. PRP therapy holds potential as a valuable adjunctive approach in the comprehensive management of knee OA, offering hope for improved quality of life and enhanced mobility for patient suffering from arthritic knee pain.



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